Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis – Results of the randomized controlled Vienna omega-3 study

S Smesny; B Milleit; MR Schaefer; J Hesse; M Schlögelhofer; K Langbein; UC Hipler; M Berger; DR Cotter; H Sauer; PD McGorry; GP Amminger

Journal article

Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis – Results of the randomized controlled Vienna omega-3 study

S Smesny, B Milleit, MR Schaefer, J Hesse, M Schlögelhofer, K Langbein, UC Hipler, M Berger, DR Cotter, H Sauer, PD McGorry, GP Amminger

Schizophrenia Research | ELSEVIER SCIENCE BV | Published : 2017

DOI: 10.1016/j.schres.2017.01.026

Abstract

Alterations of immune function have been reported in ultra-high risk (UHR) for psychosis patients causing expectations in terms of predictive meaningfulness and benefits of anti-inflammatory agents. According to a RCT in UHR-patients supplementation of omega-3 polyunsaturated fatty acids (PUFA) was effective in reducing transition to psychosis risk and to improve symptomatology. Based on preclinical findings, we now investigated state marker properties of and the influence of PUFA on immune markers in a RCT (clinical trials.gov Identifier: NCT00396643). In a longitudinal design we measured plasma levels of the pro-inflammatory interleukin 6 (IL-6), the soluble alpha (Tac) subunit of the inte..

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University of Melbourne Researchers

Maximus Berger Author

Patrick McGorry Author

Paul Amminger Author

Related Projects (2)

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EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

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Grants

Awarded by Stanley Medical Research Institute

Funding Acknowledgements

The study was supported by a Stanley Medical Research Institute Grant (03T-315). In performing the analysis of pro-inflammatory and oxidative stress markers, Dr. Stefan Smesny was supported by the German Research Foundation (DFG), Grant Sm 68/3-1. Dr. G Paul Amminger was supported by the National Health and Medical Research Council of Australia (No. 566529). Dr. Maximus Berger was supported by a JCU Postgraduate Research Scholarship. The authors like to thank all sponsors for their continuous support.